Progynon-Depot contains estradiol valerate, a synthetic analogue of the natural female sex hormone estradiol. It is used in hormone replacement therapy (HRT) to compensate for estrogen deficiency in women.

Indications for Use:

1. Menopausal Syndrome:
   • Relief of symptoms associated with estrogen deficiency in peri- and postmenopause, such as hot flashes, sweating, sleep disturbances, irritability, and more.
2. Prevention of Osteoporosis:
   • For postmenopausal women at increased risk of fractures, particularly if other medications are contraindicated or poorly tolerated.
3. Hypoestrogenic Conditions:
   • Due to hypogonadism, castration, or primary ovarian insufficiency.

Contraindications:

• Known hypersensitivity to estradiol or any components of the drug.
• Pregnancy and Breastfeeding.
• Estrogen-Dependent Tumors: Confirmed or suspected (e.g., breast or endometrial cancer).
• Unexplained Vaginal Bleeding.
• Acute or Chronic Liver Diseases.
• Thromboembolic Diseases: Active or with a history of conditions such as deep vein thrombosis or pulmonary embolism.
• Severe Hypertension.

Side Effects:

1. Endocrine System:
   • Changes in body weight, fluid retention, altered libido.
2. Nervous System:
   • Headache, dizziness, depressive states.
3. Digestive System:
   • Nausea, vomiting, abdominal pain.
4. Skin:
   • Skin rash, pruritus (itching), chloasma (pigmentation changes).
5. Cardiovascular System:
   • Elevated blood pressure, thromboembolic complications.
6. Other:
   • Soreness or tightness at the injection site.

Special Instructions:

1. Pre-Therapy Examination:
   • A comprehensive medical evaluation is required before initiating therapy, including a gynecological exam and mammography.
2. Regular Monitoring:
   • Periodic medical examinations are recommended during treatment to assess the patient’s condition and evaluate therapy effectiveness.
3. Thromboembolism Risk:
   • In women with an increased risk of thromboembolic complications, carefully weigh the benefit-to-risk ratio before prescribing.
4. Laboratory Interference:
   • Estrogens may influence the results of certain laboratory tests. Inform medical personnel of the medication use before testing.
5. Consultation Required:
   • Before starting Progynon-Depot, consult a healthcare provider to determine the appropriateness of treatment and the optimal dosage. Self-medication is strongly discouraged and may lead to adverse outcomes.

• Solution for intramuscular injection.
• Ampules of 1 ml containing 10 mg of the active substance dissolved in an oil base (usually benzyl benzoate and castor oil for prolonged action).
• The depot form provides a long-term effect of the drug after a single injection.