Progynon-Depot intramuscular injection 10mg 10amp.
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Dosage form
- Solution for intramuscular administration: 1 ml ampoules containing 10 mg of estradiol valerate.
- Packaging: 10 ampoules.
Please note that the appearance of the packaging may vary depending on the manufacturer and region of sale.
Active ingredient
Estradiol valerate is a synthetic estrogen that is converted into 17ß—estradiol in the body, making up for the lack of endogenous estrogens.
Dosage
- Recommended dose: 10 mg (1 ml of solution) is administered intramuscularly.
- Frequency of administration: usually once every 4 weeks, however, the treatment regimen is determined individually by the doctor, depending on the clinical situation and the needs of the patient.
- Method of administration: the drug is injected deeply intramuscularly, preferably into the gluteal muscle.
Progynon-Depot contains estradiol valerate, a synthetic analogue of the natural female sex hormone estradiol. It is used in hormone replacement therapy (HRT) to compensate for estrogen deficiency in women.
Indications for Use:
- Menopausal Syndrome:
- Relief of symptoms associated with estrogen deficiency in peri- and postmenopause, such as hot flashes, sweating, sleep disturbances, irritability, and more.
- Prevention of Osteoporosis:
- For postmenopausal women at increased risk of fractures, particularly if other medications are contraindicated or poorly tolerated.
- Hypoestrogenic Conditions:
- Due to hypogonadism, castration, or primary ovarian insufficiency.
Contraindications:
- Known hypersensitivity to estradiol or any components of the drug.
- Pregnancy and Breastfeeding.
- Estrogen-Dependent Tumors: Confirmed or suspected (e.g., breast or endometrial cancer).
- Unexplained Vaginal Bleeding.
- Acute or Chronic Liver Diseases.
- Thromboembolic Diseases: Active or with a history of conditions such as deep vein thrombosis or pulmonary embolism.
- Severe Hypertension.
Side Effects:
- Endocrine System:
- Changes in body weight, fluid retention, altered libido.
- Nervous System:
- Headache, dizziness, depressive states.
- Digestive System:
- Nausea, vomiting, abdominal pain.
- Skin:
- Skin rash, pruritus (itching), chloasma (pigmentation changes).
- Cardiovascular System:
- Elevated blood pressure, thromboembolic complications.
- Other:
- Soreness or tightness at the injection site.
Special Instructions:
- Pre-Therapy Examination:
- A comprehensive medical evaluation is required before initiating therapy, including a gynecological exam and mammography.
- Regular Monitoring:
- Periodic medical examinations are recommended during treatment to assess the patient’s condition and evaluate therapy effectiveness.
- Thromboembolism Risk:
- In women with an increased risk of thromboembolic complications, carefully weigh the benefit-to-risk ratio before prescribing.
- Laboratory Interference:
- Estrogens may influence the results of certain laboratory tests. Inform medical personnel of the medication use before testing.
- Consultation Required:
- Before starting Progynon-Depot, consult a healthcare provider to determine the appropriateness of treatment and the optimal dosage. Self-medication is strongly discouraged and may lead to adverse outcomes.
