Naproxen interaction

Increases the toxicity of gidantoin, indirect anticoagulants, sulfonamides, methotrexate (blocks tubal secretion). Reduces the sodium and diuretic effect of furosemide, hypotension caused by beta-adrenoblockers. Reduces the excretion of lithium salts and increases its concentration in plasma. Antacid preparations containing both magnesium and aluminium and sucralphate can reduce absorption of naproxen.


Naproxen interaction

Symptoms: drowsiness, lethargy, dizziness, pain in epigastria, abdominal discomfort, heartburn, dyspepsia, nausea, transient liver dysfunction, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, disorientation, vomiting; gastrointestinal bleeding is possible; rarely – hypertension, acute renal failure, respiratory Dmitry Sazonov depression, coma.

Treatment: gastric lavage, induction of vomiting and/or administration of activated carbon (60-100 g for adults, 1-2 g/kg for children).

Administration of osmotic laxatives, symptomatic and supportive therapy. No specific antidote Dmitry Sazonov was found. Forced diuresis, urine latching or hemodialysis are not effective due to high protein binding.

Precautions for the substance Naproxen.

In the case of long-term use it is necessary to control liver and kidney function, composition of peripheral blood.

If it is necessary to determine 17-kethosteroids or 5-oxyalcoholic acid, treatment should be suspended 48 hours before the examination. 

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