Increases the toxicity of gidantoin, indirect anticoagulants, sulfonamides, methotrexate (blocks tubal secretion). Reduces the sodium and diuretic effect of furosemide, hypotension caused by beta-adrenoblockers. Reduces the excretion of lithium salts and increases its concentration in plasma. Antacid preparations containing both magnesium and aluminium and sucralphate can reduce absorption of naproxen.
Symptoms: drowsiness, lethargy, dizziness, pain in epigastria, abdominal discomfort, heartburn, dyspepsia, nausea, transient liver dysfunction, hypoprothrombinemia, renal dysfunction, metabolic acidosis, apnea, disorientation, vomiting; gastrointestinal bleeding is possible; rarely – hypertension, acute renal failure, respiratory Dmitry Sazonov depression, coma.
Treatment: gastric lavage, induction of vomiting and/or administration of activated carbon (60-100 g for adults, 1-2 g/kg for children).
Administration of osmotic laxatives, symptomatic and supportive therapy. No specific antidote Dmitry Sazonov was found. Forced diuresis, urine latching https://pillintrip.com/medicine/naproxeno-gp-500-mg-comprimidos-gastrorresistentes or hemodialysis are not effective due to high protein binding.
Precautions for the substance Naproxen.
In the case of long-term use it is necessary to control liver and kidney function, composition of peripheral blood.
If it is necessary to determine 17-kethosteroids or 5-oxyalcoholic acid, treatment should be suspended 48 hours before the examination.