Mecobalamin is the active coenzyme form of vitamin B₁₂, used in the treatment of various neurological and hematological disorders.

Indications for Use:

1. Pernicious Anemia.
2. Megaloblastic Anemia caused by vitamin B₁₂ deficiency.
3. Diabetic and Alcoholic Polyneuropathy.
4. Trigeminal Neuralgia.
5. Down Syndrome.
6. Infantile Cerebral Palsy.
7. Peripheral Nerve Injuries.

Contraindications:

• Known hypersensitivity to mecobalamin or any other components of the drug.
• Erythremia, erythrocytosis, or thromboembolism.

Side Effects:

1. Allergic Reactions:
   • Skin rash, pruritus (itching), urticaria (hives).
2. Cardiovascular System:
   • Tachycardia, chest pain (pain in the heart area).
3. Nervous System:
   • Headache, dizziness, agitation.
4. Other:
   • Diarrhea, hypercoagulability when used in high doses.

Special Instructions:

1. Monitoring Blood Parameters:
   • Regular monitoring of peripheral blood parameters is recommended during prolonged use.
2. Drug Interactions:
   • Mecobalamin may enhance allergic reactions caused by thiamine.
   • Avoid combining with drugs that increase blood coagulation.
3. Pregnancy and Lactation:
   • Use is permitted only under strict medical indications and supervision.
4. Consultation Recommended:
   • Before starting treatment with Mecobalamin, consult a healthcare provider to assess the appropriateness of therapy and determine the optimal dosage. Self-medication is strongly discouraged and may result in adverse effects.