Medrol Tablets 4mg 100tab.
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Dosage form
- Tablets: white, elliptical in shape, with crossed notches on one side and “UPJOHN” engraving on the other.
- Dosage: 4 mg of methylprednisolone in each tablet.
- Packaging: 100 tablets.
Please note that the appearance of the packaging may vary depending on the manufacturer and region of sale.
Active ingredient
Methylprednisolone is a synthetic glucocorticosteroid with potent anti-inflammatory and immunosuppressive effects.
Dosage
- Initial dose for adults: from 4 mg to 48 mg of methylprednisolone per day, depending on the disease and the patient's response to therapy.
- Maintenance dose: determined individually by gradually reducing the initial dose to the minimum effective dose.
- How to use: tablets are taken orally, drinking enough water, preferably in the morning to mimic the natural circadian rhythm of cortisol secretion.
- Children: dosage is calculated based on body weight or body surface area; consultation with a physician is recommended to determine the exact dose.
Medrol is the trade name for a medication containing methylprednisolone, a synthetic glucocorticosteroid (GCS) with anti-inflammatory, immunosuppressive, and anti-allergic properties.
Indications for Use:
- Endocrine Disorders:
- Primary or secondary adrenal insufficiency.
- Rheumatic Diseases:
- Rheumatoid arthritis.
- Osteoarthritis.
- Ankylosing spondylitis.
- Collagen Diseases:
- Systemic lupus erythematosus.
- Systemic dermatomyositis (polymyositis).
- Skin Diseases:
- Vesiculobullous disorders.
- Severe forms of psoriasis.
- Allergic Conditions:
- Severe or debilitating allergic reactions unresponsive to standard therapy.
- Ophthalmologic Diseases:
- Severe inflammatory processes, including uveitis and iridocyclitis.
- Respiratory Diseases:
- Sarcoidosis.
- Symptomatic berylliosis.
- Hematological Disorders:
- Specific types of anemia and thrombocytopenia.
- Gastrointestinal Diseases:
- Ulcerative colitis.
- Crohn’s disease.
- Neurological Disorders:
- Acute exacerbations of multiple sclerosis.
Contraindications:
- Active systemic fungal infections.
- Known hypersensitivity to methylprednisolone or any excipients.
- Concurrent administration of live viral vaccines.
Side Effects:
- Endocrine System:
- Adrenal dysfunction, Cushing's syndrome, growth retardation in children.
- Metabolism:
- Hyperglycemia, hypokalemia, sodium and fluid retention.
- Musculoskeletal System:
- Osteoporosis, myopathy, aseptic necrosis of bones.
- Digestive System:
- Gastric or duodenal ulcers, pancreatitis.
- Nervous System:
- Mood disorders, seizures, increased intracranial pressure.
- Immune System:
- Increased susceptibility to infections, masking of infection symptoms.
- Skin:
- Skin thinning, delayed wound healing, striae formation.
Special Instructions:
- Condition Monitoring:
- Regular monitoring of blood pressure, blood glucose levels, electrolyte balance, and bone density is required during long-term use.
- Infections:
- Methylprednisolone may mask infection symptoms and increase the risk of new infections. Caution is advised in patients with chronic infections.
- Pregnancy and Lactation:
- Use only under strict medical supervision when clearly indicated.
- Drug Withdrawal:
- Gradual tapering is required after long-term treatment to avoid withdrawal syndrome.
- Consultation Required:
- Always consult a healthcare provider before starting treatment with Medrol to determine the appropriateness of therapy and establish the correct dosage. Self-medication is strongly discouraged and may result in adverse effects.
