Ketas contains the active substance ibudilast, which has anti-inflammatory, vasodilating and neuroprotective properties. The drug is used for the treatment and prevention of bronchial asthma, chronic cerebrovascular diseases and some neurological disorders.

Indications for use:

1. Bronchial asthma:

• To prevent asthma attacks and reduce their frequency.
• To reduce airway inflammation and improve lung function.

2. Chronic cerebrovascular disorders:

• Conditions associated with impaired blood flow to the brain, including ischemia.
• Support of brain function in chronic ischemia or vascular disorders.

3. Peripheral neuropathy:

• Treatment of neurologic disorders caused by nerve inflammation.
• Reduction of pain syndrome associated with peripheral nerve damage.

4. Multiple sclerosis:

• As part of a comprehensive therapy to slow disease progression.
• Reducing inflammation and supporting nervous system function.

5. Chronic Obstructive Pulmonary Disease (COPD):

• Relief of symptoms, improving quality of life for patients with respiratory distress.

6. Other inflammatory conditions:

• Including autoimmune or inflammatory processes where it is necessary to reduce inflammation and improve microcirculation.

Contraindications:

1. Hypersensitivity to ibudilast or other components of the drug.
2. Severe liver dysfunction.
3. Pregnancy and lactation: no safety data are available.
4. Pediatric age: it is not recommended to use in children without a doctor's prescription.

Side effects:

1. Gastrointestinal tract:

• Nausea, vomiting.
• Diarrhea or constipation.
• Discomfort in the abdominal area.

2. On the part of the nervous system:

• Headache.
• Drowsiness, dizziness.
• Irritability, increased fatigue.

3. Allergic reactions:

• Rash, itching.
• In rare cases - angioedema.

4. Cardiovascular system:

• Palpitations (tachycardia).
• Fluctuations in blood pressure.

5. General reactions:

• Fever, increased sweating.
• Deterioration of general well-being.

Precautions:

• Monitoring of liver function: regular monitoring of hepatic parameters is recommended during long-term use.
• Alcohol: avoid alcohol consumption during treatment.
• Co-administration with other drugs: consult a physician before use with other drugs to avoid drug interactions.

Notes:

• Treatment with ibudilast is under the supervision of a physician.
• Indications for use may vary depending on the patient's condition and the region where the drug is used.