100 mg tablets.
Allopurinol is an inhibitor of xanthine oxidase, an enzyme involved in the formation of uric acid.
The initial dose is 100-300 mg per day. The dosage is adjusted depending on the level of uric acid in the blood.
Maintenance dose: 100-200 mg per day (for mild hyperuricemia) or 300-600 mg per day (for moderate hyperuricemia).
Maximum dose: 800 mg per day.
Tablets should be taken orally after meals, drinking enough water.
Allopurinol is a drug used to reduce uric acid levels in the blood and urine, intended for the treatment of gout and other conditions accompanied by hyperuricemia.
Indications
- treatment and prevention of gout
- increased amount of uric acid in the blood
- high content of uric acid in the urine at full therapeutic fasting and therapy with antitumor drugs.
Contraindications
- severe liver and kidney dysfunction
- hypersensitivity to the drug Allopurinol.
Side effects
- digestive disorders,
- liver dysfunction,
- weakness,
- headache,
- visual disturbances,
- impotence,
- rash,
- skin redness,
- itching,
- changes in blood count.
Interaction
In concomitant use, allopurinol increases the effect of coumarin anticoagulants, adenine arabinoside, as well as hypoglycemic drugs (especially in renal dysfunction).
Uricosuric agents and salicylates in high doses reduce the activity of allopurinol.
In concomitant use of allopurinol and cytostatics, myelotoxic effect is more often manifested than in separate use.
In concomitant use of allopurinol and azathioprine or mercaptopurine, cumulation of the latter in the body is observed, because due to inhibition by allopurinol of xanthine oxidase activity, necessary for biotransformation of drugs, their metabolism and elimination is slowed down.
Overdose
Symptoms: nausea, vomiting, diarrhea, dizziness, oliguria. Treatment: forced diuresis, hemo- and peritoneal dialysis.
